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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLCG2
All Species:
22.73
Human Site:
Y818
Identified Species:
45.45
UniProt:
P16885
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P16885
NP_002652.2
1265
147870
Y818
Y
G
T
R
I
Q
Q
Y
F
P
S
N
Y
V
E
Chimpanzee
Pan troglodytes
XP_001147944
1265
147906
Y818
Y
G
T
R
I
Q
Q
Y
F
P
S
N
Y
V
E
Rhesus Macaque
Macaca mulatta
XP_001111677
1265
147898
Y818
Y
G
T
K
I
Q
Q
Y
F
P
S
N
Y
V
E
Dog
Lupus familis
XP_546812
1252
146274
Y818
Y
G
T
R
I
Q
Q
Y
F
P
S
N
Y
V
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8CIH5
1265
147573
Y818
Y
G
T
R
I
Q
Q
Y
F
P
S
N
Y
V
E
Rat
Rattus norvegicus
P24135
1265
147716
Y818
Y
G
T
R
I
Q
Q
Y
F
P
S
N
Y
V
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508105
991
115582
D557
V
E
D
I
S
T
V
D
F
E
E
L
E
K
Q
Chicken
Gallus gallus
Q2VRL0
637
72514
I203
K
G
C
R
C
L
E
I
D
C
W
D
G
S
N
Frog
Xenopus laevis
Q32NH8
758
87399
I324
Q
S
S
I
E
G
Y
I
R
A
L
K
R
G
C
Zebra Danio
Brachydanio rerio
A5D6R3
784
89362
L350
T
E
P
Y
I
R
A
L
N
Q
G
C
R
C
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624101
1134
132613
I700
D
D
G
S
V
Y
G
I
P
G
Y
M
D
P
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784329
940
107748
G506
G
Q
N
A
T
L
L
G
N
L
Q
K
G
A
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98
94.4
N.A.
94.1
94.7
N.A.
62.7
20.7
22.1
21.2
N.A.
N.A.
40.9
N.A.
32.9
Protein Similarity:
100
99.9
99.2
97
N.A.
97.1
97.3
N.A.
67.8
33.2
37.5
34.9
N.A.
N.A.
59.1
N.A.
49
P-Site Identity:
100
100
93.3
100
N.A.
100
100
N.A.
6.6
13.3
0
6.6
N.A.
N.A.
0
N.A.
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
13.3
26.6
6.6
13.3
N.A.
N.A.
6.6
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
9
0
0
9
0
0
9
0
0
0
9
0
% A
% Cys:
0
0
9
0
9
0
0
0
0
9
0
9
0
9
9
% C
% Asp:
9
9
9
0
0
0
0
9
9
0
0
9
9
0
0
% D
% Glu:
0
17
0
0
9
0
9
0
0
9
9
0
9
0
50
% E
% Phe:
0
0
0
0
0
0
0
0
59
0
0
0
0
0
0
% F
% Gly:
9
59
9
0
0
9
9
9
0
9
9
0
17
9
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
17
59
0
0
25
0
0
0
0
0
0
0
% I
% Lys:
9
0
0
9
0
0
0
0
0
0
0
17
0
9
0
% K
% Leu:
0
0
0
0
0
17
9
9
0
9
9
9
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% M
% Asn:
0
0
9
0
0
0
0
0
17
0
0
50
0
0
9
% N
% Pro:
0
0
9
0
0
0
0
0
9
50
0
0
0
9
0
% P
% Gln:
9
9
0
0
0
50
50
0
0
9
9
0
0
0
9
% Q
% Arg:
0
0
0
50
0
9
0
0
9
0
0
0
17
0
0
% R
% Ser:
0
9
9
9
9
0
0
0
0
0
50
0
0
9
0
% S
% Thr:
9
0
50
0
9
9
0
0
0
0
0
0
0
0
9
% T
% Val:
9
0
0
0
9
0
9
0
0
0
0
0
0
50
17
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% W
% Tyr:
50
0
0
9
0
9
9
50
0
0
9
0
50
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _